Testing for free radical damage is an important indicator of potentially severe health problems. Excess free radicals lead to free radical damage that has been linked to problems such as rapid aging. Revelar is a breakthrough in accurate measurement of free radical damage through a non-invasive, breath testing system that looks for free radical damage in patients. Revelar ultimately helps doctors make effective preventative health care recommendations.

Elevated levels of free radical damage can contribute to a host of health problems. Free radical activity can result in tissue damage that potentially leads to chronic conditions such as arthritis, cancer, diabetes, strokes, Alzheimer's disease as well as rapid aging.

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by Stephen H. Mastin, PhD

Excess free radicals can lead to a condition called oxidative stress. When the body does not have enough natural antioxidants to protect it from the reactive oxygen based free radicals that we produce, our cell tissues can be attacked by the excess free radicals present, resulting in oxidative stress. Oxidative stress measurement provides critical measures of how effectively antioxidants are protecting cells from excess free radicals. It is also a measure of how our antioxidants are protecting us from excess free radicals.

Given its broad impact, there is a clear need in many areas of health care and biological research for a method that can simply and accurately measure oxidative stress levels using a non-invasive sampling method. This novel and proprietary technology is called Revelar.

Download Whitepaper: Oxidative Stress Measurement

Aldehydes are the byproducts of oxidative stress. Aldehyde measurement has proven to be an effective biomarker of excess free radicals. The Revelar test is based on research relating to aldehyde measurement in exhaled breath condensate. Subsequent studies have shown a correlation between breath aldehydes and disease states. The Revelar score is in effect an aldehyde score based on testing aldehyde levels.

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by Ruthie Harper, M.D.

The Revelar device has been created to measure the balance between the production of free radicals in an individual’s body, and the body’s ability to neutralize those free radicals at any given point in time—a condition called oxidative stress. The increasing interest in free radicals, in both the lay and scientific communities, has made the market ripe for a tool that monitors the link between free radicals, oxidative stress, and disease. The Revelar system provides a score to help doctors determine the amount of oxidative stress present. It can also be called an aldehyde score, health score or rapid aging score. The Revelar score helps people make educated lifestyle decisions that may improve their health. Additionally, it can be used to determine the type and amount of nutritional supplementation an individual takes to potentially decrease their risk of disease.

Download Whitepaper: Oxidative Stress Test & the Revelar Score

by Raymond F. Akers, Jr., Ph.D.

The Revelar Free Radical Assay (“ Revelar Assay”) has been developed to detect free radicals in the form of aldehydes in breath condensate. This oxidative assay or oxidative stress assay is comprised of two components: a digital, electronic analyzer, and a single-use disposable tube. The reagents contained in the Revelar tube act to absorb breath condensate that reacts with a reagent that produces a color. The tube is then inserted into the Revelar analyzer where the color is analyzed for a free radical assay. The results are displayed as Revelar units, ranging from 0-99,999. Increasing Revelar units indicate increased levels of free radical damage in the breath condensate assay.

Download Whitepaper: The Revelar™ Free Radical Assay

In 2005, Pulse Health decided to develop non-invasive testing for the measurement of the effects of reactive oxygen species (ROS or "free radicals"), also called oxidative stress. It is also a form of anti-aging technology. The Free Radical Theory of Anti-Aging holds that free radicals, in excess, contribute to a number of health conditions, including increased risk of cardiac disease, cancer and other effects of premature aging, just as the damage caused by ROS is also known to be the mechanism of expression after exposure to toxins.

Download Whitepaper: Non-Invasive Testing Development

by David Chernoff, MD

A diagnostic test involving human measurement involves factors that can affect the consistency of the measurement. In measuring aldehydes, Revelar provides an indicator of oxidative stress and free radical activity resulting in a health test that can help limit biological noise. When measured in rapid sequence, the Revelar device has shown itself to be consistent—in fact, it is within the range of many laboratory medical devices. However, any effort to measure the effect on a human being over time of certain phenomena, such as the effect of antioxidants, is affected by something known as "biological noise."

Download Whitepaper: Biological Factors in Measuring Aldehydes

Medical diagnostics are powerful tools that help clinicians distinguish health from various disease states, and even have the potential to predict future outcomes. Breath assessment has been used since classical Greek times to assist in medical diagnosis, but recently has benefited from major technological advances in chemical assay methods.

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In a controlled study, antioxidant supplements showed reduction in pain and oxidative stress in patients with chronic pancreatitis. This study and others included here help show the benefits of antioxidant supplements in various clinical studies. The clinical evidence points to the benefits of specific antioxidant supplements for select disease states.

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The TBARS blood test for measuring oxidative stress has been widely criticized.

Thiobarbituric reactive substances test (TBARS) is the most prevalent test for lipid peroxidation. However, it is widely criticized due to lack of consistency and its reliance on a single aldehyde, MDA, as an oxidative stress marker.

Read more about oxidative stress and TBAR testing…