In a controlled study, antioxidant supplements showed reduction in pain and oxidative stress in patients with chronic pancreatitis. This study and others included here help show the benefits of antioxidant supplements in various clinical studies. The clinical evidence points to the benefits of specific antioxidant supplements for select disease states.

Download PDF: Antioxidants Reduce Pain, Oxidative Strees in Chronic Pancreatitis

Administration of vitamins C and E for 4 weeks in moderate doses showed a reduction in specific marker of oxidative stress in claudicants (persons with vascular-based leg pain).

Download PDF: Antioxidants reduce Oxidative Stress in Claudicants

In a study from the Linus Pauling Institute, no evidence was found correlating reduction of oxidative stress with administration of antioxidant supplements, with the possible exception of vitamins C and E.

The results are mixed with respect to the efficacy of antioxidants in reducing free radical damage. One significant example of antioxidant supplements showing a major impact in human health is the AREDS study, where the National Eye Institute found a reduction in age-related advance stage macular degeneration as a result of intervention of antioxidants and zinc.

Download PDF: Antioxidant Supplements for Health: An Introduction

Antioxidant supplements such as N-acetylcysteine are effective at attenuating increases in the capacity of neutrophils to generate ROS when stimulated in vitro, whereas vitamin E reduces tissue infiltration of neutrophils during exercise.

Download PDF: Neutrophil activation, antioxidant supplements and exercise-induced oxidative stress

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